Integrated pharmacokinetic/viral dynamic model for daclatasvir/asunaprevir in treatment of patients with genotype 1 chronic hepatitis C
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چکیده
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15 صفحه اولViral kinetics during the first month of treatment in patients with genotype 1 chronic hepatitis C.
OBJECTIVE to identify predictive factors of response to pegylated interferon alpha-2b and ribavirin in patients with genotype 1 chronic hepatitis C. Viral kinetics were studied in weeks 2 and 4. METHODS a prospective and consecutive study of patients with genotype 1 chronic hepatitis C referred to our Hepatology Clinic between January 2004 and October 2006 for antiviral treatment. Baseline da...
متن کاملPharmacist intervention in treatment of patients with genotype 1 chronic hepatitis C.
Chronic hepatitis C infection affects nearly 300 million people worldwide. It is one of the main causes of chronic liver disease and the most common indication for liver transplantation.1-5 There are 6 major strains or genotypes of hepatitis C virus (HCV). These genotypes have different geographic distributions, with the type 1 genotype (HCV-1) most common in the United States (accounting for a...
متن کاملReal-life efficacy of generic sofosbuvir/ledipasvir for treatment of Iranian patients with chronic hepatitis C: A cohort study
Background: Treatment of hepatitis C virus (HCV) infection with recently introduced direct-acting antiviral agents (DAA) is effective and safe, however there is little known regarding safety and efficacy of generic DAAs in the real-life clinical setting. This study aimed to evaluate the efficacy and safety of generic sofosbuvir/ledipasvir (SOF/LDV) in a real-life clinical experience. Methods: ...
متن کاملImpact of ribavirin dose reduction during treatment in chronic hepatitis C genotype 1 patients
Chronically hepatitis C virus (HCV) infects about 180 million people worldwide and it is a major cause of serious liver disease. As sustained virological response (SVR) to anti-HCV therapy avoids progression of liver fibrosis, decreases the risk of hepatocellular carcinoma and improve the survival of patients, antiviral therapy is considered as a crucial option in the management of chronic HCV ...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2017
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2017.84